HNSCC: Tumour Antigens and Their Targeting by Immunotherapy
نویسندگان
چکیده
منابع مشابه
Retroviral targeting to tumour antigens
The development of efficient, cell surface targeted retroviral vectors is critical for successful gene therapy as gene delivery to non-target cells may be harmful and would deplete the pool of viral particles. To date, the only surface-targeting strategies that have allowed efficient infection by retroviral vectors in vivo are those that have limited the tropism of amphotropic murine leukaemia ...
متن کاملTargeting cytomegalovirus (CMV) antigens for GBM immunotherapy
Despite aggressive and incapacitating conventional therapy, glioblastoma multiforme (GBM) remains uniformly lethal. Immunotherapy in which the immune system (particularly cellular effectors such as T cells) is harnessed to specifically attack malignant cells offers a treatment option with less toxicity. The presence of CMV antigens in GBM, and not in normal brain tissue presents a unique opport...
متن کاملCancer Immunotherapy by Targeting IDO1/TDO and Their Downstream Effectors
The tryptophan (TRP) to kynurenine (KYN) metabolic pathway is now firmly established as a key regulator of innate and adaptive immunity. A plethora of preclinical models suggests that this immune tolerance pathway - driven by the key and rate-limiting enzymes indoleamine-2,3-dioxygenase and TRP-2,3-dioxygenase - is active in cancer immunity, autoimmunity, infection, transplant rejection, and al...
متن کاملTumour Antigens Recognized by Antibodies
Considerable progress has been made in the last few decades in the identification of defined tumour-associated antigens recognized by monoclonal antibodies (mAbs). The generation of mAbs against tumour antigens has principally been through standard hybridoma techniques following immunization of mice, while in the last decade recombinant phage display technology has also been employed. Much of t...
متن کاملDendritic Cells and Their Role in Cancer Immunotherapy
Dendritic cells (DCs) are antigen presenting cells with unique capability to take up and process antigens in the peripheral blood and tissues. They subsequently migrate to draining lymph nodes where they present these antigens and stimulate naive T lympho-cytes. During their life cycle, DCs go through two maturation stages and are referred to as immature and mature cells, respectively. While im...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Cells
سال: 2020
ISSN: 2073-4409
DOI: 10.3390/cells9092103